用牛呼吸道合胞病毒（魁北克毒株）对犊牛进行实验性感染。
Experimental infection of calves with bovine respiratory syncytial virus (Quebec strain).
作者信息
Elazhary M A, Galina M, Roy R S, Fontaine M, Lamothe P
出版信息
Can J Comp Med. 1980 Oct;44(4):390-5.
An experiment was designed to evaluate the clinical, haematological, viral and serological aspects of bovine respiratory syncytial virus infection in calves. Eleven calves were inoculated intranasally with bovine respiratory syncytial virus (Quebec strain) in aerosol. Clinical, haemotological and serological responses of the calves and virus shedding were monitored. The experimentally infected animals manifested moderate to severe signs of respiratory disease. The parameters used to evaluate the severity of the disease included ocular discharge, conjunctivitis, lung sounds, nasal discharge, pyrexia and leukopenia. The animals were scored accordingly (scale infected 70.8-148.5, control 22-29.3). Highest disease scores were observed between day 6-9 after infection. Virological and serological assessment demonstrated that the observed clinical picture was due to bovine respiratory syncytial virus infection.
设计了一项实验，以评估犊牛感染牛呼吸道合胞病毒后的临床、血液学、病毒学和血清学方面的情况。11头犊牛经气溶胶方式经鼻接种牛呼吸道合胞病毒（魁北克毒株）。监测犊牛的临床、血液学和血清学反应以及病毒排出情况。实验感染的动物表现出中度至重度的呼吸道疾病症状。用于评估疾病严重程度的参数包括眼分泌物、结膜炎、肺部声音、鼻分泌物、发热和白细胞减少。相应地对动物进行评分（感染组70.8 - 148.5，对照组22 - 29.3）。感染后第6至9天观察到最高疾病评分。病毒学和血清学评估表明，观察到的临床症状是由牛呼吸道合胞病毒感染引起的。
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