Robertson D I, Cooney T P
Cancer. 1980 Dec 15;46(12):2623-33. doi: 10.1002/1097-0142(19801215)46:12<2623::aid-cncr2820461215>3.0.co;2-u.
A right carotid body paraganglioma (CBP) was removed from a 30-year-old female after finding metastases to cervical lymph nodes. The tumor and its metastases were studied by light and electron microscopy to determine the neoplastic cell type. Light microscopy confirmed the presence of chief cells but was inadequate alone to exclude sustentacular cells. By electron microscopy, only chief cells were found in both the primary and secondary tumors. This is the first report of an ultrastructural study of a metastasis from a malignant CBP. From our observation, we suggest that CBP be defined as a proliferation of chief and sustentacular cells. Electron microscopy is essential to determine the cell types present and thereby help classify the lesion as a tumor or hyperplasia of the carotid body.
一名30岁女性在发现颈部淋巴结转移后，切除了右侧颈动脉体副神经节瘤（CBP）。对肿瘤及其转移灶进行光镜和电镜研究以确定肿瘤细胞类型。光镜证实存在主细胞，但仅靠光镜不足以排除支持细胞。通过电镜观察，原发肿瘤和转移肿瘤中均仅发现主细胞。这是关于恶性CBP转移灶超微结构研究的首例报道。根据我们的观察，我们建议将CBP定义为主细胞和支持细胞的增殖。电镜对于确定所存在的细胞类型至关重要，从而有助于将病变分类为颈动脉体肿瘤或增生。
