Dougherty T J, Thoma R E, Boyle D G, Weishaupt K R
Cancer Res. 1981 Feb;41(2):401-4.
Photoradiation therapy, a new method for treatment of solid malignant tumors, depends upon the tumor localization and retention of hematoporphyrin derivative, which is activated in vivo by light in the red region of the spectrum. As currently applied to cutaneous and s.c. lesions, the light dose is limited by both normal tissue reactions and the effective penetration of the light through the tissues. In this report, primary solid malignant lesions in pet cats and dogs have been treated by interstitial photoradiation therapy by applying the activating light from a laser [635 +/- 5 (S. D.) nm] directly into the tumor masses thrugh a 200-micrometer quartz fiber optic. Twelve of 14 lesions (four osteosarcomas, two squamous cell carcinomas, two malignant melanomas, one mast cell sarcoma, one fibrosarcoma, one sebaceous gland sarcoma, and a metastatic prostatic carcinoma) responded to treatment, and three are currently considered permanently controlled at 1 year or more following treatment. This method has not only allowed photoradiation therapy to be applied to some remote lesions but has also nearly eliminated normal tissue effects, thus greatly extending the applicability of this treatment to a wide range of human tumors.
光辐射疗法是一种治疗实体恶性肿瘤的新方法，它依赖于肿瘤对血卟啉衍生物的定位和潴留，血卟啉衍生物在光谱的红光区域被体内的光激活。目前应用于皮肤和皮下病变时，光剂量受到正常组织反应和光穿透组织的有效深度的限制。在本报告中，通过一根200微米的石英光纤将来自激光[635±5（标准差）纳米]的激活光直接导入肿瘤块中，对宠物猫和狗的原发性实体恶性病变进行了间质光辐射治疗。14个病变中有12个（4个骨肉瘤、2个鳞状细胞癌、2个恶性黑色素瘤、1个肥大细胞肉瘤、1个纤维肉瘤、1个皮脂腺肉瘤和1个转移性前列腺癌）对治疗有反应，3个在治疗后1年或更长时间目前被认为已得到永久性控制。这种方法不仅使光辐射疗法能够应用于一些深部病变，而且几乎消除了对正常组织的影响，从而大大扩展了这种治疗方法对多种人类肿瘤的适用性。
