Théon A P, Barthez P Y, Madewell B R, Griffey S M
Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
J Am Vet Med Assoc. 1994 Aug 15;205(4):566-9.
Nine dogs and 9 cats with ceruminous gland carcinoma were evaluated to determine whether they would receive radiation therapy. Tissue samples were reviewed to confirm the diagnosis and to assess completeness of resection in animals that had undergone surgery. Seven animals were excluded because surgical excision was determined histologically to have been complete (5) or because the owners did not wish to pursue treatment, because of advanced disease (2). The remaining 6 cats and 5 dogs, 6 of which had previously undergone surgery, were included in the study. The radiation therapy dose was 48 Gy, given in 12 fractions over 4 weeks. The product-limit estimate of mean progression-free survival time was 39.5 months. The estimate of 1-year progression-free survival rate was 56%. The tumor recurred in 4 animals, and metastases were observed in 3 animals. Radiation therapy was found to be safe and effective.
对9只患有耳垢腺肿瘤的犬和9只患有耳垢腺肿瘤的猫进行评估，以确定它们是否接受放射治疗。对组织样本进行复查，以确诊并评估已接受手术的动物的切除完整性。7只动物被排除，原因是组织学检查确定手术切除完整（5只），或者由于病情晚期，主人不希望继续治疗（2只）。其余6只猫和5只犬被纳入研究，其中6只此前接受过手术。放射治疗剂量为48 Gy，分12次在4周内给予。平均无进展生存时间的乘积限估计值为39.5个月。1年无进展生存率估计值为56%。4只动物出现肿瘤复发，3只动物出现转移。结果发现放射治疗安全有效。
