Gottlieb S L, Edmiston W A, Haywood L J
Chest. 1980 Dec;78(6):880-2. doi: 10.1378/chest.78.6.880.
Cardiac toxicity is a major complication which limits the use of adriamycin as a chemotherapeutic agent. Cardiomyopathy is frequent when the total dose exceeds 600 mg/m2 and occurs within one to six months after cessation of therapy. A patient is reported who developed progressive cardiomyopathy two and one-half years after receiving 580 mg/m2 which apparently represents late, late cardiotoxicity.
心脏毒性是限制阿霉素作为化疗药物使用的主要并发症。当总剂量超过600mg/m²时，心肌病很常见，且在治疗停止后的一到六个月内发生。据报道，有一名患者在接受580mg/m²治疗两年半后出现进行性心肌病，这显然代表了迟发性、晚期心脏毒性。
