Lovett Doust J W, Christie H
Chronobiologia. 1980 Oct-Dec;7(4):505-11.
A post-menopausal woman suffering from a circular type manic depressive psychosis who had been treated by drugs was followed for 8 months on a self-reporting mood rating scale. The drug regimen was continued over a further 8 months but with the addition of 5 nights of sleep deprivation at the depth of her recurrent depressed moods. Time series analyses of the subject's longitudinal mood scores revealed a persistent cycle of 32 days. After 5 sleep deprivation treatments this cycle shortened to 28 days which endured at least for the ensuing 8 months. After sleep deprivation and decrease of the amplitude, an improvement of mood was obtained. It is suggested that the increased LD ratio obtained in sleep deprivation may be as therapeutic as the actual loss of sleep itself.
一名患有循环型躁狂抑郁症的绝经后女性，此前一直通过药物治疗，采用自我报告情绪评分量表对其进行了8个月的跟踪。药物治疗方案又持续了8个月，但在她反复出现抑郁情绪最严重时增加了5个晚上的睡眠剥夺。对该受试者纵向情绪得分的时间序列分析显示，存在一个持续32天的周期。经过5次睡眠剥夺治疗后，这个周期缩短到了28天，并且至少在随后的8个月里持续存在。睡眠剥夺并降低振幅后，情绪得到了改善。有人认为，睡眠剥夺中获得的较高的慢波睡眠与快波睡眠比值可能与实际睡眠缺失本身具有同样的治疗效果。
