Lovett Doust J W, Munro A, Christie H
Biol Psychiatry. 1980 Oct;15(5):741-8.
An ambulant patient with a regular series of mood changes constantly varying between retarded depression and hypomania on a 32- to 36-day cycle was studied for 39 weeks. The patient completed a daily self-assessment of the 11-point Dorland mood scale each evening. This scale encompasses a range of moods varying from depression through euthymia to mania. Weekly recordings each lasting 65 min were made of resting heart rate, 14 parameters derived from electrical impedance plethysmography of the head together with arterial blood pressures before and after each recording. Results were correlated with the changing mood scores. Time series analysis of the mood scores yielded a recurrent mood cycle of 35 days unchanged by such drug treatments as had been prescribed by the psychiatrist. The mood score correlated positively with the impedance amplitude, inflow angle, and transit times, and negatively with percent rise time, heart rate, and blood pressures. Amplitudes, rise times, and CT2 were independent of heart rate and blood pressures and hence probably related more closely to cerebral blood flow.
对一名门诊患者进行了39周的研究，该患者情绪有规律地变化，在32至36天的周期内，持续交替出现迟滞性抑郁和轻躁狂。患者每晚完成一次11分的多兰情绪量表的每日自我评估。该量表涵盖了从抑郁到心境正常再到躁狂的一系列情绪。每周进行一次时长65分钟的记录，记录静息心率、从头部电阻抗容积描记法得出的14项参数以及每次记录前后的动脉血压。结果与情绪得分的变化相关。对情绪得分进行时间序列分析得出，35天的周期性情绪循环不受精神科医生所开药物治疗的影响。情绪得分与阻抗幅度、流入角度和通过时间呈正相关，与上升时间百分比、心率和血压呈负相关。幅度、上升时间和CT2与心率和血压无关，因此可能与脑血流量关系更密切。
