Holmes G K, Dunn G I, Cockel R, Brookes V S
Gut. 1980 Nov;21(11):1010-5. doi: 10.1136/gut.21.11.1010.
Adenocarcinoma of the small intestine complicating coeliac disease is uncommon. Only 14 cases have been reported, and in only one of these was a jejunal biopsy carried out more than eight months before the diagnosis of malignancy. We describe four more patients with this association, all with long histories of coeliac disease, confirmed in three by jejunal biopsy over five years before the diagnosis of malignancy. Important presenting features of carcinoma were abdominal pain, anaemia, occult gastrointestinal bleeding, abdominal mass, and intestinal obstruction, and these were the main indications for operation. After resection of the tumour survival may be prolonged, as evidenced by one of our cases who remains well eight years after surgery.
小肠腺癌并发乳糜泻并不常见。仅报道过14例，其中只有1例在恶性肿瘤诊断前8个多月进行了空肠活检。我们在此描述另外4例有这种关联的患者，他们均有长期的乳糜泻病史，其中3例在恶性肿瘤诊断前5年多通过空肠活检得以确诊。癌症的重要表现特征为腹痛、贫血、隐匿性胃肠道出血、腹部肿块和肠梗阻，这些是主要的手术指征。肿瘤切除后生存期可能延长，我们的1例患者术后8年情况良好就是证明。
