Rampertab S D, Forde K A, Green P H R
Columbia University College of Physicians and Surgeons, New York 10032, USA.
Gut. 2003 Aug;52(8):1211-4. doi: 10.1136/gut.52.8.1211.
There is an increased risk of small bowel adenocarcinoma in patients with coeliac disease compared with the normal population. It has been suggested that adenocarcinoma of the small intestine in coeliac disease arises through an adenoma-carcinoma sequence but there has been only one reported case of a small bowel adenoma in a patient with coeliac disease. We report three additional cases of a small bowel adenoma in the setting of coeliac disease. In addition, four cases of small bowel adenocarcinoma are also reported, one of which was found adjacent to a jejunal villous adenoma. These cases emphasise the risk of the development of small bowel neoplasia for patients with coeliac disease and support the concept that small bowel adenocarcinoma in coeliac disease arises from adenomas.
与正常人群相比，乳糜泻患者患小肠腺癌的风险增加。有人提出，乳糜泻患者的小肠腺癌是通过腺瘤-癌序列发生的，但仅有一例乳糜泻患者发生小肠腺瘤的报道。我们报告另外三例乳糜泻患者发生小肠腺瘤的病例。此外，还报告了四例小肠腺癌病例，其中一例在空肠绒毛状腺瘤附近发现。这些病例强调了乳糜泻患者发生小肠肿瘤的风险，并支持乳糜泻患者的小肠腺癌起源于腺瘤的观点。
