[Clinical symptoms and therapy of the hereditary angioneurotic edema (author's transl)].

Sera of 333 patients showing clinical symptoms of "Quincke edema" have been tested for their deficiency of C1 esterase inhibitor. The diagnosis "Hereditary Angio Neurotic Edema" (HANE) could be stated in 39 cases, i.e. 11.9%. Clinical manifestations consisted of peripheral edema (80%), abdominal colics (77%), and facial edema (72%). Edema of the larynx have been observed in 51% of the cases. 10 patients have been treated with purified C1 esterase inhibitor during the attack as a substitutional therapy, and 10 patients received danazol during their attackfree intervals. Both of these treatments were therapeutically successful.