Liebman W M
J Clin Gastroenterol. 1980 Sep;2(3):243-6. doi: 10.1097/00004836-198009000-00007.
Basal and histalog-stimulated gastric acid secretion and serum gastrin levels before and after a standard protein meal were compared in eight children with active duodenal ulcer (DU), four with active gastric ulcer (GU), and in seven children with recurrent abdominal pain (RAP) of undetermined etiology. There was no discernible difference in the pattern of abdominal pain in DU, GU, and RAP. Basal acid output, peak and maximal acid output, whether expressed as milliequivalents per hour or as milliequivalents per kilogram per hour, were comparable in children with DU, GU, and RAP. In contrast, serum gastrin levels, 1 and 2 hours after standard protein meal, were significantly higher in the DU children than in the GU or RAP group. These studies have suggested that hypersecretion of gastric acid may not be associated with duodenal ulcer or gastric ulcer disease in children, and that increased gastrin secretion and possible reduced acid responsiveness coexist in children with duodenal ulcers.
对8名患有活动性十二指肠溃疡（DU）的儿童、4名患有活动性胃溃疡（GU）的儿童以及7名病因不明的复发性腹痛（RAP）儿童，比较了标准蛋白质餐后基础胃酸分泌和组胺刺激胃酸分泌以及血清胃泌素水平。DU、GU和RAP患儿的腹痛模式没有明显差异。DU、GU和RAP患儿的基础酸排出量、峰值酸排出量和最大酸排出量，无论以每小时毫当量还是每千克每小时毫当量表示，均具有可比性。相比之下，标准蛋白质餐后1小时和2小时，DU患儿的血清胃泌素水平显著高于GU或RAP组。这些研究表明，胃酸分泌过多可能与儿童十二指肠溃疡或胃溃疡疾病无关，十二指肠溃疡患儿同时存在胃泌素分泌增加和可能的酸反应性降低。
