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放射性碘:生物动力学、平均剂量及剂量分布

Radioiodine: biokinetics, mean dose and dose distribution.

作者信息

Kaul A, Roedler H D

出版信息

Radiat Environ Biophys. 1980;18(3):185-95. doi: 10.1007/BF01323597.

DOI:10.1007/BF01323597
PMID:7454972
Abstract

For the radioiodine isotopes I-123, I-125, I-131, and I-132 the mean tissue dose and local dose distribution in the epithelial cells of a follicle have been calculated and compared to each other. Moreover, dose factors have been estimated for I-131 as a function of age considering age-dependent ingestion (milk consumption) and inhalation rates. Thereby, besides age-dependent biological half-times and thyroid masses, the thyroidal iodine uptake was assumed to be independent from age and taken to be about 1.7 the normal for an insufficient dietary iodine intake as in the Federal Republic of Germany.

摘要

对于放射性碘同位素I - 123、I - 125、I - 131和I - 132,已计算出卵泡上皮细胞中的平均组织剂量和局部剂量分布,并进行了相互比较。此外,还根据年龄依赖性摄入(牛奶消耗量)和吸入率,估算了I - 131的剂量系数。因此,除了年龄依赖性生物半衰期和甲状腺质量外,假定甲状腺碘摄取与年龄无关,并设定为德国饮食碘摄入不足时正常摄取量的约1.7倍。

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本文引用的文献

1
Estimates of absorbed fractions for monoenergetic photon sources uniformly distributed in various organs of a heterogeneous phantom.对于均匀分布在非均匀体模各器官中的单能光子源的吸收分数估计值。
J Nucl Med. 1969 Aug:Suppl 3:7-52.
2
Distribution of absorbed dose around point sources of electrons and beta particles in water and other media.水及其他介质中电子和β粒子点源周围吸收剂量的分布。
J Nucl Med. 1971 Mar:Suppl 5:5-23.
3
Summary of current radiation dose estimates to humans from 123I, 124I, 125I, 126I, 130I, 131I, and 132I as sodium iodide.
以碘化钠形式存在的123I、124I、125I、126I、130I、131I和132I对人类当前辐射剂量估计的总结
J Nucl Med. 1975 Sep;16(9):857-60.
4
Microscopic dose distributions due to iodine isotopes in thyroid.甲状腺中碘同位素引起的微观剂量分布。
Radiat Environ Biophys. 1978 Oct 12;15(3):229-39. doi: 10.1007/BF02176792.
5
A computer simulation study of optimal thyroid radiation protection during investigations involving the administration of radioiodine-labelled pharmaceuticals.一项关于在涉及给予放射性碘标记药物的检查过程中甲状腺最佳辐射防护的计算机模拟研究。
Br J Radiol. 1978 Apr;51(604):265-72. doi: 10.1259/0007-1285-51-604-265.
6
Local distribution of energy deposition in and around the follicles of a 125I contaminated thyroid.¹²⁵I污染的甲状腺滤泡内及周围的能量沉积局部分布
Curr Top Radiat Res Q. 1978 Jan;12(1-4):12-32.