Seńczuk W, Młynarczyk W
Med Pr. 1978;29(5):365-70.
Animals, used for experiments, were intoxicated intratracheally with a suspension of grinding, ceramic or welding dust, in a NaCl solution. These studies demonstrated that the ceramic and welding dusts, used in the experiment, showed a rather great biological activity. This has been proved by the increased weight of dried lungs, and increased total content of some aminoacids in lungs, e.g. hydroxyproline, which is thought to be a reliable index of fibrosis of the pulmonary tissue, as well as of the change in the morphological structure of lungs. Parrallel to the mentioned changes of the lungs, the content of free aminoacids in the animals blood plasma has been remarkably reduced. The results described in this paper prove that there is a dependence between the content of aminoacids in the blood plasma and the changes in lungs caused by dust.
用于实验的动物通过气管内注入悬浮于氯化钠溶液中的研磨粉尘、陶瓷粉尘或焊接粉尘而中毒。这些研究表明，实验中使用的陶瓷粉尘和焊接粉尘具有相当大的生物活性。这已通过干燥肺重量的增加以及肺中某些氨基酸总含量的增加得到证明，例如羟脯氨酸，它被认为是肺组织纤维化以及肺形态结构变化的可靠指标。与上述肺部变化平行的是，动物血浆中游离氨基酸的含量显著降低。本文所述结果证明，血浆中氨基酸含量与粉尘引起的肺部变化之间存在关联。
