Dindogru A, Barcos M, Henderson E S, Wallace H J
Med Pediatr Oncol. 1978;5(1):65-71. doi: 10.1002/mpo.2950050110.
Two hundred and fifty-six patients with a wide variety of advanced neoplasms who were treated with adriamycin at Roswell Park Memorial Institute were studied for electrocardiographic changes. All the patients had pre- and posttreatment electrocardiograms (ECG's) and changes were found in 85 (33.2%). In the group of 1-8 patients with normal pretreatment ECG's, changes occurred in 51 (30.3%). In the group of 88 patients who had abnormal pretreatment ECG's, 34 (38.6%) developed further changes following treatment. Twenty-five patients received cytoxan concomitantly and ECG changes developed in 12 (48%); however, this and the above difference were not statistically significant. Frequency of ECG changes was higher and the extent of histologic abnormality in the myocardium was greater in those patients who received high doses of adriamycin. Arrythmias were rather benign and only a small number of patients required treatment. ECG changes following adriamycin treatment occurred more frequently than previously reported.
对在罗斯韦尔帕克纪念研究所接受阿霉素治疗的256例患有各种晚期肿瘤的患者进行了心电图变化研究。所有患者在治疗前和治疗后均进行了心电图检查，发现85例（33.2%）有变化。在治疗前心电图正常的1 - 8例患者组中，51例（30.3%）出现了变化。在88例治疗前心电图异常的患者组中，34例（38.6%）在治疗后出现了进一步变化。25例患者同时接受了环磷酰胺治疗，12例（48%）出现了心电图变化；然而，这一情况以及上述差异均无统计学意义。接受高剂量阿霉素治疗的患者心电图变化频率更高，心肌组织学异常程度更大。心律失常较为良性，只有少数患者需要治疗。阿霉素治疗后的心电图变化比以前报道的更为频繁。
