Weaver S K, Fulkerson P K, Lewis R P, Leier C V
J Electrocardiol. 1978 Jul;11(3):233-8. doi: 10.1016/s0022-0736(78)80122-8.
Serial electrocardiograms (ECGs) of 49 patients receiving adriamycin were analyzed for the development of persistent changes. The ECG changes were compared with those of a control group of 20 patients receiving other chemotherapeutic drugs, which were comparable to the additional chemotherapy received by the adriamycin patients. The only chronic ECG changes noted with adriamycin over control were the loss of P wave amplitude in the greater than 500 mg/m2 dose subgroup and the clockwise rotation of the precordial QRS in the 250-500 mg/m2 dose subgroup. In contrast, systolic time intervals demonstrated a gradual diminution in left ventricular function at increasing doses of adriamycin. The electrocardiogram itself appears to be of limited value in the assessment of cardiac toxicity with adriamycin therapy.
对49例接受阿霉素治疗的患者的系列心电图（ECG）进行分析，以观察持续性变化的发生情况。将这些ECG变化与20例接受其他化疗药物的对照组患者的变化进行比较，这些对照组患者接受的其他化疗与阿霉素治疗组患者额外接受的化疗相当。与对照组相比，阿霉素治疗唯一观察到的慢性ECG变化是剂量大于500mg/m²亚组中P波振幅降低，以及剂量在250 - 500mg/m²亚组中胸前导联QRS波顺时针旋转。相比之下，随着阿霉素剂量增加，收缩期时间间期显示左心室功能逐渐减退。心电图本身在评估阿霉素治疗的心脏毒性方面似乎价值有限。
