Nakamuro K, Yoshikawa K, Sayato Y, Kurata H
Mutat Res. 1978 Nov;58(2-3):175-81. doi: 10.1016/0165-1218(78)90007-1.
The comparative cytogenetic and mutagenic effects between trivalent and hexavalent chromium were investigated. Five chromium compounds, K2Cr2O7 and K2CrO4 containing Cr6+, and Cr(CH3COO)3, Cr(NO3)3 and CrCl3 containing Cr3+, were examined for their ability to induce chromosomal damage in cultures of human leukocytes, for their reactivity with DNA by a rec-assay system and for mutagenicity in the E. coli Hs30R test system. Chromosome-breaking activity was significantly higher for the compounds with hexavalent than trivalent chromium, the efficiency being in the decreasing order K2Cr2OM greater than K2CrO4 greater than Cr(CHCOO)3 greater than Cr(NO3)3, CrCl3. In the rec-assay and mutation assay, hexavalent (K2Cr2O7 and K2CrO4) and trivalent Cr(CH3COO)3) compounds gave positive results, their mutagenic potential being higher in the same order of clastogenic magnitude.
研究了三价铬和六价铬的细胞遗传学和诱变效应的比较。研究了五种铬化合物，含Cr6+的K2Cr2O7和K2CrO4，以及含Cr3+的Cr(CH3COO)3、Cr(NO3)3和CrCl3，检测它们在人白细胞培养物中诱导染色体损伤的能力、通过重组检测系统与DNA的反应性以及在大肠杆菌Hs30R测试系统中的诱变性。六价铬化合物的染色体断裂活性明显高于三价铬化合物，效率顺序为K2Cr2O7＞K2CrO4＞Cr(CH3COO)3＞Cr(NO3)3＞CrCl3。在重组检测和突变检测中，六价铬（K2Cr2O7和K2CrO4）和三价铬（Cr(CH3COO)3）化合物给出阳性结果，它们的诱变潜力按相同的致断裂程度顺序更高。
