既往石棉工人痰液与肺部石棉小体计数的比较。

Comparison of sputum and lung asbestos body counts in former asbestos workers.

作者信息

Roggli V L, Greenberg S D, McLarty J W, Hurst G A, Hieger L R, Farley M L, Mabry L C

出版信息

Am Rev Respir Dis. 1980 Dec;122(6):941-5. doi: 10.1164/arrd.1980.122.6.941.

DOI:10.1164/arrd.1980.122.6.941

Abstract

The asbestos (ferruginous) body content of lung tissues was compared to the number of asbestos bodies (AB) in sputum from 6 former amosite asbestos workers. Lung tissue was obtained at autopsy (5 subjects) and lobectomy (1 subject), and AB content was determined by a digestion-concentration technique. The sputum obtained was collected by both spontaneous cough (a pooled, 3-day specimen) and aerosolized hypertonic saline induction. Four slides treated with Papanicolaou's stain were prepared from each cytologic specimen and scored from 0 to 3 + on the basis of the total number of AB counted on the 4 slides. A significant correlation (P < 0.02) was found between the number of AB per gram of lung tissue and the percentage of sputum specimens from each worker than were positive for AB. Asbestos bodies were identified in 46% of sputum specimens from the 4 workers whose lungs contained 900 or more AB/g of lung tissue.

摘要

比较了6名曾接触铁石棉的石棉工人肺组织中的石棉（含铁）小体含量与痰液中石棉小体（AB）的数量。肺组织取自尸检（5例）和肺叶切除术（1例），AB含量通过消化浓缩技术测定。采集的痰液通过自然咳嗽（一份3天的混合标本）和气雾状高渗盐水诱导获得。从每个细胞学标本中制备4张经巴氏染色的玻片，并根据4张玻片上计数的AB总数从0到3+进行评分。发现每克肺组织中AB的数量与每名工人痰液标本中AB阳性的百分比之间存在显著相关性（P<0.02）。在肺组织中AB含量为900或更多AB/g的4名工人的46%的痰液标本中鉴定出石棉小体。