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一名患有肢端皮炎的婴儿存在锌依赖性趋化缺陷。

Zinc-dependent chemotactic defect in an infant with acrodermatitis.

作者信息

Businco L, Menghi A M, Rossi P, D'Amelio R, Galli E

出版信息

Arch Dis Child. 1980 Dec;55(12):966-8. doi: 10.1136/adc.55.12.966.

Abstract

A 5-month-old infant developed acrodermatitis enteropathica when weaned from breast milk to cows' milk. Plasma zinc concentration was low. T- and B-lymphocyte functions were normal, but there was a severe defect of neutrophil chemotaxis. Oral treatment with zinc sulphate (40 mg daily) induced an immediate clinical improvement, with restoration of normal plasma zinc level and complete correction of neutrophil chemotaxis.

摘要

一名5个月大的婴儿在从母乳断奶改为牛奶喂养时患上了肠病性肢端皮炎。血浆锌浓度较低。T淋巴细胞和B淋巴细胞功能正常,但中性粒细胞趋化性存在严重缺陷。口服硫酸锌(每日40毫克)使临床症状立即改善,血浆锌水平恢复正常,中性粒细胞趋化性完全纠正。

本文引用的文献

2
Acrodermatitis enteropathica with immune deficiency.
J Pediatr. 1973 Dec;83(6):1007-11. doi: 10.1016/s0022-3476(73)80536-0.
5
Zinc therapy of acrodermatitis enteropathica.
N Engl J Med. 1975 Apr 24;292(17):879-82. doi: 10.1056/NEJM197504242921702.
7
Zinc binding: a difference between human and bovine milk.锌结合:人乳与牛乳的差异。
Science. 1977 Feb 25;195(4280):789-90. doi: 10.1126/science.836589.

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