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[谷硫磷对小鼠的胚胎毒性和致畸性]

[Embryotoxicity and teratogenicity of phosmet in mice].

作者信息

Bleyl D W

出版信息

Arch Exp Veterinarmed. 1980;34(5):791-5.

PMID:7458565
Abstract

Pregnant mice were treated with Phosmet, an organophosphorus insecticide. The doses were 6.2 mg/kg body weight and 15.5 mg/kg body weight and 15.5 mg/kg body weight, together with four-per-cent ethoxose as suspension fluid. Applications were repeated between the first and 15th or between the first and eighth days of pregnancy. Some of the animals received only one single application, between the 4th and 13th days of pregnancy. Established effects, caused by the substance proper included sex shifting among living foetuses, retardation of development, and reduced ossification.

摘要

怀孕小鼠用有机磷杀虫剂亚胺硫磷进行处理。剂量分别为6.2毫克/千克体重、15.5毫克/千克体重和15.5毫克/千克体重,并以4%的乙醇糖作为悬浮液。在怀孕的第1天至第15天之间或第1天至第8天之间重复用药。一些动物在怀孕的第4天至第13天之间仅用药一次。该物质本身产生的既定影响包括存活胎儿的性别转变、发育迟缓以及骨化减少。

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1
[Embryotoxicity and teratogenicity of phosmet in mice].[谷硫磷对小鼠的胚胎毒性和致畸性]
Arch Exp Veterinarmed. 1980;34(5):791-5.
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