具有不同转移能力的肿瘤亚系在宿主体内诱导相似的血液凝固变化。
Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
作者信息
Delaini F, Giavazzi R, De Bellis Vitti G, Alessandri G, Mantovani A, Donati M B
出版信息
Br J Cancer. 1981 Jan;43(1):100-4. doi: 10.1038/bjc.1981.14.
This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.
本文旨在研究转移性肿瘤生长如何影响宿主的止血系统。在小鼠纤维肉瘤（mFS6）或其具有不同转移能力的亚系之一的生长和转移过程中的不同时间间隔，测定血小板计数、血纤维蛋白原水平、活化部分凝血活酶时间（APTT）和凝血酶原时间（PT）。在所有研究的动物组中，无论各亚系的转移潜能如何，在肿瘤发展过程中均观察到进行性血小板减少和纤维蛋白原水平升高。PT或APTT值未观察到显著变化。这些数据支持这样的概念，即原发性生长而非转移性生长影响荷瘤动物的止血系统。
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