Sarma Dipti, Saikia Uma K, Das Darvin V
Department of Endocrinology, Gauhati Medical College, Guwahati, Assam, India.
Indian J Endocrinol Metab. 2018 Mar-Apr;22(2):212-216. doi: 10.4103/ijem.IJEM_652_17.
The neonatal skeletal outcomes due to maternal Vitamin D deficiency.
The aim of this study is to assess the serum 25 hydroxy Vitamin D (25[OH]D) status in pregnant women and correlate with cord blood 25(OH)D levels, femur length at 34 weeks gestation, and neonatal anthropometry (birth weight, birth length, and head circumference).
This was prospective cohort study.
This study was carried out in 250 healthy primigravida between 18 and 40 years of age in the third trimester of gestation attending the Obstetrics and Gynaecology Department of Gauhati Medical College, Guwahati from December 2012 to December 2015. Dietary assessment of calcium and Vitamin D intake, sunlight exposure among the pregnant mothers and fetal femur length measurements were done. The neonates were followed up at birth for biometric assessment and the estimation of cord 25(OH)D.
Chi-square test and Pearson correlation were carried out to see the association and correlation between different variables. Statistical significance was set at the 0.05 level.
We found low Vitamin D levels (60%) in the majority of pregnant mothers and newborns (62.4%). The mean Vitamin D levels were 17.51 ± 2.24 ng/ml and 14.51 ± 1.8 ng/ml among the low Vitamin D maternal subjects and their new born, respectively. There was a significant association of maternal Vitamin D levels with sun exposure, dietary intake of Vitamin D, serum calcium, serum alkaline phosphatase levels, and serum parathyroid hormone in subjects with low Vitamin D. Fetal femur length and birth length were significantly shorter in mothers with low Vitamin D ( < 0.01).
Maternal hypovitaminosis D was associated with adverse skeletal outcome in neonates.
母亲维生素D缺乏所致的新生儿骨骼结局。
本研究旨在评估孕妇血清25羟维生素D（25[OH]D）水平，并将其与脐血25(OH)D水平、妊娠34周时的股骨长度以及新生儿人体测量指标（出生体重、出生身长和头围）进行关联分析。
这是一项前瞻性队列研究。
本研究于2012年12月至2015年12月在高哈蒂医学院妇产科就诊的250名年龄在18至40岁之间、处于妊娠晚期的健康初产妇中进行。对孕妇进行了钙和维生素D摄入量的饮食评估、阳光暴露情况以及胎儿股骨长度测量。新生儿出生时进行随访，以进行生物测量评估并测定脐血25(OH)D。
采用卡方检验和Pearson相关性分析来观察不同变量之间的关联和相关性。统计学显著性设定为0.05水平。
我们发现大多数孕妇（60%）和新生儿（62.4%）的维生素D水平较低。维生素D水平较低的孕妇及其新生儿的平均维生素D水平分别为17.51±2.24 ng/ml和14.51±1.8 ng/ml。维生素D水平较低的孕妇中，母亲的维生素D水平与阳光暴露、维生素D饮食摄入量、血清钙、血清碱性磷酸酶水平以及血清甲状旁腺激素之间存在显著关联。维生素D水平较低的母亲所生胎儿的股骨长度和出生身长显著较短（<0.01）。
母亲维生素D缺乏与新生儿不良骨骼结局相关。
