The effect of histamine and epinephrine on adenylate cyclase prepared from dog ventricle.

The possible presence of histamine H2 receptors in dog ventricle was investigated by determining the effect of histamine on adenylate cyclase prepared from that tissue. Epinephrine produced a dose-dependent increase in adenylate cyclase activity but histamine had no effect. Histamine H2 receptors probably do not exist in dog ventricle.