Naidoo S P, Owen D A
Can J Surg. 1981 Jan;24(1):87-90.
Primary malignant anal tumours were studied in 6 men and 11 women at the Health Sciences Centre in Winnipeg between Jan. 1, 1968 and Dec. 31, 1977. The patients ranged in age from 46 to 85 years (mean 64 years). Histologically, over 70% of tumours were either cloacogenic or squamous carcinomas. A variety of other lesions were encountered, reflecting the complex embryologic development of this region. The most frequent presenting complaints were a mass at the anus and rectal bleeding. Abdominoperineal resection, with or without radiotherapy, was the preferred treatment, but in a few cases local excision was effective. During the follow-up period, eight patients died, an average of 2 years after diagnosis. The remaining nine patients have survived an average of 6 years; two have recurrent tumour.
1968年1月1日至1977年12月31日期间，在温尼伯市健康科学中心对6名男性和11名女性的原发性肛管恶性肿瘤进行了研究。患者年龄在46岁至85岁之间（平均64岁）。组织学上，超过70%的肿瘤为泄殖腔源癌或鳞状细胞癌。还发现了多种其他病变，这反映了该区域复杂的胚胎发育过程。最常见的主诉是肛门肿物和直肠出血。腹会阴联合切除术，无论是否联合放疗，是首选的治疗方法，但在少数情况下局部切除也有效。在随访期间，8名患者死亡，平均在诊断后2年。其余9名患者平均存活了6年；2名患者肿瘤复发。
