Pereira M A, Chang L W
Chem Biol Interact. 1981 Jan;33(2-3):301-5. doi: 10.1016/0009-2797(81)90048-x.
The alkylation of hemoglobin is a proposed dose monitor for chemical carcinogens and mutagens. The binding of fifteen chemical carcinogens and mutagens to rat hemoglobin was determined. Direct acting carcinogens and indirect acting carcinogens including aromatic amines, halogenated hydrocarbons, nitrosamines, polycyclic aromatic hydrocarbons, aflatoxin B1 and benzene bound hemoglobin. The efficiency of carcinogen and mutagen hemoglobin was dose dependent and ranged from 0.007 to 2.3% of an oral dose. The binding of chemical carcinogens and mutagens to hemoglobin would appear to be generic so that it could be developed into a dose monitor for a large number of known carcinogens and mutagens.
血红蛋白的烷基化是一种针对化学致癌物和诱变剂的潜在剂量监测指标。测定了15种化学致癌物和诱变剂与大鼠血红蛋白的结合情况。直接作用致癌物和间接作用致癌物，包括芳香胺、卤代烃、亚硝胺、多环芳烃、黄曲霉毒素B1和苯，均能与血红蛋白结合。致癌物和诱变剂与血红蛋白的结合效率呈剂量依赖性，范围为口服剂量的0.007%至2.3%。化学致癌物和诱变剂与血红蛋白的结合似乎具有普遍性，因此有望开发成为大量已知致癌物和诱变剂的剂量监测指标。
