Foster P M, Lake B G, Thomas L V, Cook M W, Gangolli S D
Chem Biol Interact. 1981 Mar 1;34(2):233-8. doi: 10.1016/0009-2797(81)90134-4.
Mono-n-butyl, -iso-butyl, -sec-butyl or -tert-butyl esters of o-phthalic acid were orally administered at 800 mg/kg body wt./day for 6 days, to young male rats. All of the animals except those treated with the mono-tert-ester developed marked testicular atrophy. Additionally, only those isomers producing testicular damage were found to alter zinc metabolism by increasing the urinary excretion of zinc and by depleting the concentration of this element in testicular tissues.
将邻苯二甲酸的单正丁酯、单异丁酯、单仲丁酯或单叔丁酯以800毫克/千克体重/天的剂量口服给予年轻雄性大鼠，持续6天。除了用单叔丁酯处理的动物外，所有动物均出现明显的睾丸萎缩。此外，仅发现那些造成睾丸损伤的异构体通过增加锌的尿排泄量以及消耗睾丸组织中该元素的浓度来改变锌代谢。
