Dowling J N, Weyant R S, Pasculle A W
Antimicrob Agents Chemother. 1982 Aug;22(2):272-6. doi: 10.1128/AAC.22.2.272.
The bactericidal activity of five antibiotics for Legionella micdadei was determined by the construction of time-kill curves. Erythromycin, rifampin, penicillin G, cephalothin, and gentamicin were bactericidal for L. micdadei at readily achievable concentrations. The minimal bactericidal concentrations, defined as those producing 99.9% killing within 24 h, were: erythromycin, 4.6; rifampin, 0.13; penicillin G, 0.25; cephalothin, 2.5; and gentamicin, 0.25 micrograms/ml. The ratios of the minimal bactericidal to minimal inhibitory concentrations for these antibiotics ranged from 1 to 8. Thus, the poor in vivo activity of beta-lactam and aminoglycoside antibiotics against L. micdadei cannot be ascribed to a lack of killing by these agents.
通过构建时间-杀菌曲线来测定五种抗生素对米克戴德军团菌的杀菌活性。红霉素、利福平、青霉素G、头孢噻吩和庆大霉素在易于达到的浓度下对米克戴德军团菌具有杀菌作用。定义为在24小时内产生99.9%杀灭率的最低杀菌浓度分别为：红霉素4.6；利福平0.13；青霉素G 0.25；头孢噻吩2.5；庆大霉素0.25微克/毫升。这些抗生素的最低杀菌浓度与最低抑菌浓度之比在1至8之间。因此，β-内酰胺类和氨基糖苷类抗生素对米克戴德军团菌体内活性较差不能归因于这些药物缺乏杀菌作用。
