Edelstein P H, Meyer R D
Antimicrob Agents Chemother. 1980 Sep;18(3):403-8. doi: 10.1128/AAC.18.3.403.
Thirty-three isolates of Legionella pneumophila, all except one of which were clinical isolates, were tested against 20 antimicrobial agents by using an agar dilution technique. Erythromycin, rifamp]in, and rosaramycin were the most active agents tested. Aminoglycosides, chloramphenicol, and cefoxitin also inhibited the organisms at low concentrations. Other agents, including moxalactam, cefoperazone, and cephalosporins, exhibited moderate to little activity. Tetracycline, doxycycline and minocyeline were apparently inactivated by charcoal-yeast extract medium. There was slight inoculum dependence noted with most of the antimicrobials tested, particularly the beta-lactam agents. There was no consistent difference in susceptibility between Center for Disease Control-supplied stock strains and recent clinical isolates, but there were marked differences with some agents. Susceptibility testing needs to be standardized in view of the influence of inoculum size, strain variation, and the medium used.
采用琼脂稀释技术，对33株嗜肺军团菌（除1株外均为临床分离株）进行了20种抗菌药物的测试。红霉素、利福平及罗沙红霉素是测试中活性最强的药物。氨基糖苷类、氯霉素及头孢西丁在低浓度时也能抑制该菌生长。包括拉氧头孢、头孢哌酮及头孢菌素在内的其他药物，活性则为中等或较弱。四环素、多西环素及米诺环素在活性炭酵母浸出液培养基中明显失活。大多数测试抗菌药物，尤其是β-内酰胺类药物，表现出轻微的接种量依赖性。疾病控制中心提供的标准菌株与近期临床分离株之间的药敏性无一致差异，但对某些药物存在显著差异。鉴于接种量大小、菌株差异及所用培养基的影响，药敏试验需要标准化。
