Benes L, Rotreklová E, Velcovský V, Pospísil M
Folia Biol (Praha). 1980;26(6):408-14.
The effect of CAP on proliferations of bone marow cells from unirradiated and irradiated (4.78 Gy) C57BL/10 mice was investigated by 3H-dTh incorporation into DNA of individual cells using autoradiography. CAP was administered from day 7 to day 10 after irradiation. CAP decreases the rate of entry of cells into S phase and the rate of 3H-dTh incorporation into DNA during replication. Cells of the erythropoietic series are mainly involved in this decrease. CAP has roughly the same inhibitory effect on unirradiated and irradiated cell populations.
通过使用放射自显影术将³H-胸腺嘧啶脱氧核苷掺入单个细胞的DNA中，研究了CAP对未受照射和受照射（4.78 Gy）的C57BL/10小鼠骨髓细胞增殖的影响。在照射后第7天至第10天给予CAP。CAP降低了细胞进入S期的速率以及复制过程中³H-胸腺嘧啶脱氧核苷掺入DNA的速率。红细胞生成系列的细胞主要参与了这种降低。CAP对未受照射和受照射的细胞群体具有大致相同的抑制作用。
