小鼠隐窝周围成纤维细胞鞘的描述及基本细胞动力学
Description and basic cell kinetics of the murine pericryptal fibroblast sheath.
作者信息
Neal J V, Potten C S
出版信息
Gut. 1981 Jan;22(1):19-24. doi: 10.1136/gut.22.1.19.
Abstract
The size of the pericryptal fibroblast sheath (PCFS) population was determined by scoring serial sections. There are 38 and 124 PCFS cells per murine small intestinal and colonic crypt, respectively. The cells of the PCFS are slightly weighted towards the lower two-thirds of the crypt in their distribution. The ratio of epithelial cells to PCFS cells is approximately 6.5:1. The in vivo cell kinetics were analysed under control and stressed (fasted-refed) conditions. The control labelling index increases from 8.9% in the small intestine and 7.0% in the colon to peaks 49% and 113% respectively above these values 24 hours after 3HTdR administration. Labelling is observed at all crypt levels equally, and no evidence of vertical migration of labelled PCFS cells was found. Colonic epithelial and PCFS cells show a similar pattern of response to feeding after a fast of 72 hours with respect to time, but a different distribution of response in terms of crypt position.
摘要
通过对连续切片进行计数来确定隐窝周围成纤维细胞鞘（PCFS）群体的大小。每只小鼠小肠和结肠隐窝分别有38个和124个PCFS细胞。PCFS细胞在隐窝中的分布略偏向隐窝下三分之二部分。上皮细胞与PCFS细胞的比例约为6.5:1。在对照和应激（禁食-再喂食）条件下分析体内细胞动力学。对照标记指数从小肠中的8.9%和结肠中的7.0%分别在给予3HTdR后24小时增加到高于这些值的峰值49%和113%。在所有隐窝水平均观察到标记，未发现标记的PCFS细胞垂直迁移的证据。在禁食72小时后，结肠上皮细胞和PCFS细胞在时间方面对喂食表现出相似的反应模式，但在隐窝位置方面反应分布不同。
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