Farini R, Nitti D, Del Favero G, Rossi C R, Costantin G, Rebuffi A, Farini A, Piccoli A, Matarazzo R, Lise M, Naccarato R
Hepatogastroenterology. 1980 Jun;27(3):213-6.
CEA concentration in juice collected during the Secretin-Pancreozymin test, and cytology were evaluated in order to establish whether they may be used as an aid in the diagnosis of pancreatic carcinoma before resorting to x-ray examinations. Thirty-three subjects were studied: 6 normal subjects, 12 with chronic pancreatitis, 3 after recovery from acute pancreatitis, 8 with gall-stones, 3 with carcinoma of the pancreas and 1 with cancer of the biliary tract. Three duodenal juice samples (at 30, 60 and 90 mins of hormonal infusion) were taken in each subject for CEA, cytology, bicarbonate and trypsin determinations. Although a significant statistical difference was noted between normal subjects and patients with carcinoma of the pancreas in the 30-min-juice sample, CEA concentration in the duodenal juice did not seem a reliable index in the diagnosis of pancreatic carcinoma. The information provided by cytology was also very scanty and sometimes misleading. The clinical picture and radiological investigation still remain the surest basis for the diagnosis of pancreatic cancer.
为了确定在进行X线检查之前，癌胚抗原（CEA）浓度以及细胞学检查结果是否有助于胰腺癌的诊断，研究人员对促胰液素-胰酶泌素试验期间收集的果汁中的CEA浓度以及细胞学进行了评估。共对33名受试者进行了研究，其中包括6名正常受试者、12名慢性胰腺炎患者、3名急性胰腺炎康复后患者、8名胆结石患者、3名胰腺癌患者和1名胆管癌患者。每位受试者在激素输注30、60和90分钟时采集三份十二指肠液样本，用于检测CEA、进行细胞学检查、测定碳酸氢盐和胰蛋白酶。尽管在30分钟的果汁样本中，正常受试者与胰腺癌患者之间存在显著的统计学差异，但十二指肠液中的CEA浓度似乎并非诊断胰腺癌的可靠指标。细胞学检查提供的信息也非常有限，有时甚至会产生误导。临床症状和影像学检查仍然是诊断胰腺癌最可靠的依据。
