Morgan K L, Hussein A M, Newby T J, Bourne F J
Immunology. 1980 Nov;41(3):729-36.
The immunoglobulin content of porcine nasal, tracheal and bronchio-alveolar secretions was determined. IgA was the predominant immunoglobulin in nasal and tracheal secretions, there being no significant difference (P greater than 0.01) between their IgA:IgG ratios of 2.7:1 and 2.4:1, respectively. In contrast, IgG was the predominant immunoglobulin in bronchioalveolar secretions, the IgA:IgG ratio being 0.7:1. The ability of tracheal and lung tissue to synthesize IgA and IgG was determined in vitro. Tracheal cultures synthesized more IgA than IgG whereas in the lungs the reverse occurred, the ratio of IgA:IgG synthesis being 1.4:1 and 0.4:1, respectively. The proportion of serum-derived IgA and IgG in respiratory tract secretions was determined by measuring the transfer of 125I- and 131I-labelled immunoglobulins from serum. It appeared that more than 97% of the IgA was produced locally. More significantly a proportion of the IgG was also synthesized locally. This proportion was smallest in nasal secretions (21.8%) and greatest in bronchio-alveolar secretions (62.6%). The results suggest that IgG, a large proportion of which is locally synthesized, is important in the homeostatic mechanisms of the lower respiratory tract.
测定了猪鼻腔、气管和支气管肺泡分泌物中的免疫球蛋白含量。IgA是鼻腔和气管分泌物中的主要免疫球蛋白，其IgA:IgG比值分别为2.7:1和2.4:1，两者之间无显著差异（P大于0.01）。相比之下，IgG是支气管肺泡分泌物中的主要免疫球蛋白，IgA:IgG比值为0.7:1。体外测定了气管和肺组织合成IgA和IgG的能力。气管培养物合成的IgA比IgG多，而在肺中情况相反，IgA:IgG合成比值分别为1.4:1和0.4:1。通过测量血清中125I和131I标记的免疫球蛋白的转移，确定了呼吸道分泌物中血清来源的IgA和IgG的比例。似乎超过97%的IgA是局部产生的。更重要的是，一部分IgG也是局部合成的。这个比例在鼻腔分泌物中最小（21.8%），在支气管肺泡分泌物中最大（62.6%）。结果表明，大部分在局部合成的IgG在下呼吸道的稳态机制中很重要。
