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用TNP-KLH经气管内初次免疫和加强免疫后大鼠支气管相关淋巴组织（BALT）和气管旁淋巴结（PTLN）中的抗TNP形成细胞

Anti-TNP-forming cells in bronchus-associated lymphoid tissue (BALT) and paratracheal lymph node (PTLN) of the rat after intratracheal priming and boosting with TNP-KLH.

作者信息

van der Brugge-Gamelkoorn G J, Claassen E, Sminia T

出版信息

Immunology. 1986 Mar;57(3):405-9.

PMID:3514441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453822/
Abstract

The aim of the present study was to elucidate the role of the paratracheal lymph node (PTLN) and bronchus-associated lymphoid tissue (BALT) in the generation of antigen-specific antibody-forming cells after intratracheal administration of trinitrophenyl-conjugated keyhole limpet haemocyanin (TNP-KLH). Priming as well as boosting resulted in the occurrence of specific antibody-forming cells in the PTLN, in BALT and in the lung. No anti-TNP-forming cells were observed in Peyer's patch, mesenteric lymph node and popliteal lymph node. From the data on the kinetics of anti-TNP-forming cells, it is concluded that intratracheal administration of antigen leads to a locally confined plasmacellular reaction. This suggests that the migrating and/or homing capacities of memory cells generated in the lung environment (PTLN, BALT) differ from those generated in the gut.

摘要

本研究的目的是阐明气管旁淋巴结（PTLN）和支气管相关淋巴组织（BALT）在气管内给予三硝基苯基偶联的钥孔戚血蓝蛋白（TNP-KLH）后抗原特异性抗体形成细胞产生过程中的作用。初次免疫以及再次免疫均导致PTLN、BALT和肺中出现特异性抗体形成细胞。在派氏结、肠系膜淋巴结和腘淋巴结中未观察到抗TNP形成细胞。根据抗TNP形成细胞的动力学数据，得出气管内给予抗原会导致局部局限性浆细胞反应的结论。这表明在肺环境（PTLN、BALT）中产生的记忆细胞的迁移和/或归巢能力与在肠道中产生的记忆细胞不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/50110cd0922d/immunology00184-0071-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/eb2c61f1c3a9/immunology00184-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/47ac822956c3/immunology00184-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/f54cd024e5d9/immunology00184-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/50110cd0922d/immunology00184-0071-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/eb2c61f1c3a9/immunology00184-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/47ac822956c3/immunology00184-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/f54cd024e5d9/immunology00184-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/1453822/50110cd0922d/immunology00184-0071-c.jpg

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CYTOCHEMICAL DEMONSTRATION OF PEROXIDASE ACTIVITY WITH 3-AMINO-9-ETHYLCARBAZOLE.用3-氨基-9-乙基咔唑进行过氧化物酶活性的细胞化学显示
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Changes occurring in the epithelium covering the bronchus-associated lymphoid tissue of rats after intratracheal challenge with horseradish peroxidase.用辣根过氧化物酶经气管内攻击大鼠后，其支气管相关淋巴组织表面上皮发生的变化。
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