Weissberg R M, Garay G L
Int Arch Allergy Appl Immunol. 1979;59(1):85-94. doi: 10.1159/000232243.
Reproducible immediate-type respiratory responses were evoked in conscious monkeys, sensitive to inhaled Ascaris suum, for periods up to 18 months. These responses were characterized by decreases in tidal volume and increases in breathing rate that persisted for about 40 min. Maximum changes were seen 3--5 min after exposure to the aerosolized antigen and were often accompanied by coughing and increased movement of the animals within the plethysmograph used for monitoring their ventilatory changes. Significant inhibition of the Ascaris-induced respiratory changes were seen in animals treated with either isoproterenol or cromolyn sodium. However, the latter agent was not effective in reversing histamine-induced ventilatory changes. The conscious monkey appears to be a suitable animal for evaluating potential antiallergic drugs.
在对吸入猪蛔虫敏感的清醒猴子中，可诱发重复性速发型呼吸反应，持续时间长达18个月。这些反应的特征是潮气量减少和呼吸频率增加，持续约40分钟。暴露于雾化抗原后3 - 5分钟出现最大变化，常伴有咳嗽和动物在用于监测其通气变化的体积描记器内活动增加。用异丙肾上腺素或色甘酸钠治疗的动物中，猪蛔虫诱导的呼吸变化受到显著抑制。然而，后一种药物对逆转组胺诱导的通气变化无效。清醒猴子似乎是评估潜在抗过敏药物的合适动物。
