色甘酸及一种新型抗过敏药物（10-氯-1,4,6,9-四氢-4,6-二氧代吡啶并[3,2-g]喹啉-2,8-二羧酸）对过敏反应的抑制作用。II. 在灵长类动物中对雾化猪蛔虫抗原的活性。
Inhibition of allergic reactions by cromoglycate and by a new anti-allergic drug(10-chloro-1,4,6,9-tetrahydro-4,6-dioxopyrido(3,2-g)quinoline-2,8-dicarboxylic acid). II. Activity in primates against aerosolized Ascaris suum antigen.
作者信息
Johnson H G, van Hout C A
出版信息
Int Arch Allergy Appl Immunol. 1976;50(4):454-62. doi: 10.1159/000231535.
PMID:814103
Abstract
Immediate type hypersensitivity to Ascaris antigen in rhesus reactor monkeys was used to assess the pharmacologic profile of Cromolyn Na and a new inhibitor of IgE-medited lung function changes. Cutaneous reactivity to Ascaris correlated poorly with a respiratory response to antigen. Two parameters used to measure lung function, respiratory rate increase and tidal volume decrease, were significantly altered by Cromolyn Na and compound A.
摘要
利用恒河猴反应动物对蛔虫抗原的速发型超敏反应来评估色甘酸钠和一种新的IgE介导的肺功能变化抑制剂的药理学特性。皮肤对蛔虫的反应性与对抗原的呼吸反应相关性较差。用于测量肺功能的两个参数，即呼吸频率增加和潮气量减少，被色甘酸钠和化合物A显著改变。
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