急性和慢性乙型肝炎中针对乙肝核心抗原的IgM抗体反应
IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis B.
作者信息
Tedder R S, Wilson-Croome R
出版信息
J Hyg (Lond). 1981 Apr;86(2):163-72. doi: 10.1017/s002217240006887x.
Abstract
A solid phase M-antibody capture radioimmunoassay (MACRIA) and a serum fractionation method were used to quantitate the IgM response to the hepatitis B core antigen (IgM anti-HBc) in acute and chronic hepatitis B infections. Antibody to the core antigen was predominantly of the IgM class during the acute phase of hepatitis B. Resolving acute infections remained positive by MACRIA, but at decreasing levels, for as long as 6 months. IgM anti-HBc persisted in HBsAg carriers but at levels very much lower than seen in acute infections. There was no correlation of IgM anti-HBc with severity of chronic liver disease in carriers. Measurement of IgM anti-HBc by MACRIA enabled accurate identification of acute hepatitis B on single serum specimens.
摘要
采用固相M抗体捕获放射免疫测定法（MACRIA）和血清分级分离法对急性和慢性乙型肝炎感染中针对乙型肝炎核心抗原的IgM反应（IgM抗-HBc）进行定量。在乙型肝炎急性期，核心抗原抗体主要为IgM类。急性感染消退后，MACRIA检测仍呈阳性，但水平逐渐下降，可持续长达6个月。IgM抗-HBc在HBsAg携带者中持续存在，但水平远低于急性感染时所见。携带者中IgM抗-HBc与慢性肝病严重程度无相关性。通过MACRIA检测IgM抗-HBc能够在单份血清标本上准确识别急性乙型肝炎。
相似文献
1
IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis B.急性和慢性乙型肝炎中针对乙肝核心抗原的IgM抗体反应
J Hyg (Lond). 1981 Apr;86(2):163-72. doi: 10.1017/s002217240006887x.
2
Radioimmunoassay detection of IgM antibodies to the hepatitis B core antigen in HBsAg liver disease.在乙肝表面抗原（HBsAg）肝病中采用放射免疫分析法检测乙肝核心抗原的IgM抗体
Boll Ist Sieroter Milan. 1982;61(3):210-7.
3
4
IgM antibody against hepatitis B core antigen (IgM anti-HBc): diagnostic and prognostic significance in acute HBsAg positive hepatitis.抗乙型肝炎核心抗原IgM抗体（IgM抗-HBc）：在急性HBsAg阳性肝炎中的诊断及预后意义
Br Med J (Clin Res Ed). 1983 Oct 29;287(6401):1254-6. doi: 10.1136/bmj.287.6401.1254.
5
[Anti-HBc IgM in acute and chronic hepatitis B virus infection].[急性和慢性乙型肝炎病毒感染中的抗-HBc IgM]
Klin Wochenschr. 1984 Sep 3;62(17):837-42. doi: 10.1007/BF01711864.
6
Presence and meaning of anti-HBc IgM as determined by ELISA in patients with acute type B hepatitis and healthy HBsAg carriers.通过酶联免疫吸附测定法（ELISA）测定急性乙型肝炎患者和健康乙肝表面抗原（HBsAg）携带者体内抗乙肝核心抗体免疫球蛋白M（anti-HBc IgM）的存在情况及意义。
Hepatology. 1981 May-Jun;1(3):233-7. doi: 10.1002/hep.1840010307.
7
Diagnosis of acute type B hepatitis by a solid phase u-antibody capture radioimmunoassay for IgM class antibody to hepatitis B core antigen: a diagnostic proposal based on a prospective study.应用固相抗 - 抗体捕获放射免疫分析法检测乙型肝炎核心抗原IgM类抗体诊断急性乙型肝炎：一项基于前瞻性研究的诊断建议
Liver. 1987 Jun;7(3):182-7. doi: 10.1111/j.1600-0676.1987.tb00340.x.
8
Diagnostic significance of anti-HBc IgM (RIA) in healthy HBsAg carriers and in chronic hepatitis B.抗-HBc IgM（放射免疫分析）在健康HBsAg携带者及慢性乙型肝炎中的诊断意义
J Med Virol. 1986 Mar;18(3):229-34. doi: 10.1002/jmv.1890180304.
9
Immunoglobulin M antibodies against hepatitis B core antigen in patients with chronic hepatitis B infection.慢性乙型肝炎感染患者中抗乙型肝炎核心抗原的免疫球蛋白M抗体。
Pathology. 1984 Jan;16(1):83-5. doi: 10.3109/00313028409067916.
10
Predominance of immunoglobulin M antibody to hepatitis B core antigen in chronic carriers of hepatitis B surface antigen.乙肝表面抗原慢性携带者中乙肝核心抗原免疫球蛋白M抗体的优势
Am J Clin Pathol. 1984 Jan;81(1):88-90. doi: 10.1093/ajcp/81.1.88.
引用本文的文献
1
Patterns of hepatitis b virus immune escape and pol/rt mutations across clinical cohorts of patients with genotypes a, e and occult hepatitis b infection in Nigeria: A multi-centre study.在尼日利亚，对基因型 A、E 和隐匿性乙型肝炎感染的临床患者队列进行了乙型肝炎病毒免疫逃逸和 pol/rt 突变的多中心研究。
Virulence. 2023 Dec;14(1):2218076. doi: 10.1080/21505594.2023.2218076.
2
Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases.埃及慢性肝病儿童骨转换生化标志物的临床益处
World J Gastroenterol. 2007 Feb 7;13(5):785-90. doi: 10.3748/wjg.v13.i5.785.
3
The development and use of an antibody capture radioimmunoassay for specific IgM to a human parvovirus-like agent.一种针对人细小病毒样病原体特异性 IgM 的抗体捕获放射免疫测定法的开发与应用。
J Hyg (Lond). 1982 Apr;88(2):309-24. doi: 10.1017/s0022172400070169.
4
IgM antibody against hepatitis B core antigen (IgM anti-HBc): diagnostic and prognostic significance in acute HBsAg positive hepatitis.抗乙型肝炎核心抗原IgM抗体（IgM抗-HBc）：在急性HBsAg阳性肝炎中的诊断及预后意义
Br Med J (Clin Res Ed). 1983 Oct 29;287(6401):1254-6. doi: 10.1136/bmj.287.6401.1254.
5
Determination of immunoglobulin M antibodies for hepatitis B core antigen with a capture enzyme immunoassay and biotin-labeled core antigen produced in Escherichia coli.用捕获酶免疫测定法和在大肠杆菌中产生的生物素标记核心抗原测定乙型肝炎核心抗原的免疫球蛋白M抗体。
J Clin Microbiol. 1985 Oct;22(4):637-40. doi: 10.1128/jcm.22.4.637-640.1985.
6
Cutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections.用于区分急性、慢性和既往乙型肝炎病毒感染的抗病毒核心抗原免疫球蛋白M抗体的临界值水平。
J Clin Microbiol. 1986 Aug;24(2):288-93. doi: 10.1128/jcm.24.2.288-293.1986.
7
Detection of anti-HIV-1 immunoglobulin M antibodies in patients with serologically proved HIV-1 infection.
Infection. 1988 Mar-Apr;16(2):115-8. doi: 10.1007/BF01644317.
本文引用的文献
1
Hepatitis B in hospitals.
Br J Hosp Med. 1980 Mar;23(3):266, 275-6, 278-9.
2
Immunoglobulin classes of antibody to hepatitis B core antigen.针对乙肝核心抗原的抗体的免疫球蛋白类别。
J Infect Dis. 1975 Jul;132(1):1-5. doi: 10.1093/infdis/132.1.1.
3
The IgM antibody responses to the core antigen of hepatitis B virus.针对乙型肝炎病毒核心抗原的IgM抗体反应。
J Med Virol. 1978;3(2):141-9. doi: 10.1002/jmv.1890030208.
4
Liver enzyme concentrations as measure of possible infectivity in chronic asymptomatic carriers of hepatitis B.肝酶浓度作为慢性无症状乙肝携带者潜在传染性的衡量指标。
Br Med J. 1978 Dec 9;2(6152):1600-2. doi: 10.1136/bmj.2.6152.1600.
5
IgM-anti-HBc as a marker of persistent and IgG-anti-HBc as a marker of past hepatitis B infection. A longitudinal study over 5 years.IgM抗-HBc作为持续性感染的标志物，IgG抗-HBc作为既往乙型肝炎感染的标志物。一项为期5年的纵向研究。
Acta Hepatogastroenterol (Stuttg). 1978 Oct;25(5):360-4.
6
Selective detection of IgM-antibody against core antigen of the hepatitis B virus by a modified enzyme immune assay.通过改良酶免疫测定法对乙型肝炎病毒核心抗原的IgM抗体进行选择性检测。
J Med Virol. 1979;4(3):227-38. doi: 10.1002/jmv.1890040308.
7
A solid-phase radioimmunoassay for detection of IgM antibodies to hepatitis A virus.一种用于检测甲型肝炎病毒IgM抗体的固相放射免疫测定法。
J Infect Dis. 1979 Aug;140(2):169-75. doi: 10.1093/infdis/140.2.169.
8
Anti-e and rheumatoid factor activity in hepatitis B.乙型肝炎中的抗 -e 及类风湿因子活性
Lancet. 1977 Jun 11;1(8024):1262-3. doi: 10.1016/s0140-6736(77)92474-6.
Zotero 插件