Walters K A, Flynn G L, Marvel J R
J Invest Dermatol. 1981 Feb;76(2):76-9. doi: 10.1111/1523-1747.ep12525318.
Diffusion characteristics of the nail plate are necessary in providing the baselines for rational topical management of nail infections. In order to develop such baselines a unique stainless steel diffusion cell has been designed. The cell permits the exposure of 0.38 cm2 of nail plate to a bathing medium which is stirred by small motors mounted above the cell. The diffusion of water, methanol and ethanol at constant temperature (37 degrees C), has been examined over periods up to 4 h. Average permeability coefficients of water, methanol and ethanol were determined as 16.5 +/- 5.9 X 10(-3) cm hr-1, 5.6 X 10(-3) cm hr-1 and 5.8 +/- 3.1 X 10(-3) cm hr-1 respectively. Moreover rates of diffusion across the nail were inversely proportional to nail thickness. Based on methanol data, nail plate barrier property appears stable for long periods of aqueous immersion.
甲板的扩散特性对于为指甲感染的合理局部治疗提供基线是必要的。为了建立这样的基线，设计了一种独特的不锈钢扩散池。该扩散池可使0.38平方厘米的甲板暴露于由安装在扩散池上方的小电机搅拌的浴液介质中。在长达4小时的时间内，研究了水、甲醇和乙醇在恒温（37摄氏度）下的扩散情况。水、甲醇和乙醇的平均渗透系数分别测定为16.5±5.9×10⁻³厘米/小时、5.6×10⁻³厘米/小时和5.8±3.1×10⁻³厘米/小时。此外，穿过指甲的扩散速率与指甲厚度成反比。基于甲醇数据，甲板屏障特性在长时间水浸中似乎是稳定的。
