Mieli-Vergani G, Vergani D, Tredger J M, Eddleston A L, Davis M, Williams R
J Clin Lab Immunol. 1980 Jul;4(1):49-51.
Lymphocytes from three of four patients with severe unexplained hepatitis following halothane anaesthesia were cytotoxic in vitro for liver cells isolated from rabbits following halothane anaesthesia, and less so for control hepatocytes. While the latter reaction could be blocked by addition of a purified liver membrane lipoprotein (LSP), this had no effect on the cytotoxicity to "halothane" hepatocytes. These results provide evidence that patients with severe halothane-associated hepatitis are sensitised to a liver cell antigen distinct from LSP, which arises as a result of halothane anaesthesia.
在接受氟烷麻醉后出现严重不明原因肝炎的4名患者中，有3名患者的淋巴细胞在体外对从接受氟烷麻醉的兔子分离出的肝细胞具有细胞毒性，而对对照肝细胞的细胞毒性较小。虽然加入纯化的肝细胞膜脂蛋白（LSP）可阻断后一种反应，但这对“氟烷”肝细胞的细胞毒性没有影响。这些结果证明，患有严重氟烷相关性肝炎的患者对一种不同于LSP的肝细胞抗原有致敏性，这种抗原是氟烷麻醉的结果。
