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氟烷代谢产物对肝脏微粒体脂质的修饰；一项多核核磁共振光谱研究。

Modification of liver microsomal lipids by halothane metabolites; a multi nuclear NMR spectroscopic study.

作者信息

Müller R, Stier A

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(3):234-7. doi: 10.1007/BF00505492.

DOI:10.1007/BF00505492
PMID:7155205
Abstract

N-trifluoroacetyl phosphatidyl ethanolamine was found as an intermediate of biotransformation of halothane after intense in vivo exposure of non-induced and phenobarbital induced rabbits. The metabolite has been identified in detergent treated liver microsomes by 31P-NMR-spectroscopy and in microsomal lipid extracts by 19F-NMR- and 1H-NMR-spectroscopy as well as by thin layer chromatography. The same exposure changed phospholipid composition of liver microsomal membranes: most prominent was a substantial decrease of the ratio of phosphatidyl ethanolamines to phosphatidylcholines.

摘要

在未诱导和苯巴比妥诱导的兔子体内大量暴露氟烷后，发现N-三氟乙酰磷脂酰乙醇胺是氟烷生物转化的中间体。已通过31P-NMR光谱在去污剂处理的肝微粒体中以及通过19F-NMR和1H-NMR光谱以及薄层色谱在微粒体脂质提取物中鉴定出该代谢物。相同的暴露改变了肝微粒体膜的磷脂组成：最显著的是磷脂酰乙醇胺与磷脂酰胆碱的比例大幅下降。

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Modification of liver microsomal lipids by halothane metabolites; a multi nuclear NMR spectroscopic study.氟烷代谢产物对肝脏微粒体脂质的修饰；一项多核核磁共振光谱研究。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(3):234-7. doi: 10.1007/BF00505492.
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.肝微粒体的一氧化碳结合色素。II. 增溶、纯化及性质
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Lymphocyte cytotoxicity to halothane altered hepatocytes in patients with severe hepatic necrosis following halothane anaesthesia.氟烷麻醉后发生严重肝坏死的患者中，淋巴细胞对氟烷改变的肝细胞具有细胞毒性。
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1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids.1-氯-2,2,2-三氟乙基自由基：在重组囊泡中由人细胞色素P-450催化氟烷生成并与磷脂结合。
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Correspondence: the biotransformation of halothane.通信：氟烷的生物转化
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Antibody formation in response to liposomal model membranes sensitized with N-substituted phosphatidylethanolamine derivatives.针对用N-取代磷脂酰乙醇胺衍生物致敏的脂质体模型膜产生的抗体形成。
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A universal reagent for phospholipid analysis.一种用于磷脂分析的通用试剂。
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9
Urinary metabolites of halothane in man.氟烷在人体中的尿液代谢产物。
Anesthesiology. 1975 Oct;43(4):392-401. doi: 10.1097/00000542-197510000-00004.
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Preparation of liver microsomes with high recovery of endoplasmic reticulum and a low grade of contamination.制备具有高内质网回收率和低污染程度的肝微粒体。
Biochim Biophys Acta. 1978 Mar 21;508(1):155-64. doi: 10.1016/0005-2736(78)90197-9.