镰状细胞病患儿的肺炎球菌感染：发病率增加、免疫缺陷、疫苗失效及未来展望
Pneumococcal infections in children with sickle cell disease: increased incidence, immunological defects, vaccine failure, and prospects for the future.
作者信息
Lembo N J
出版信息
J Natl Med Assoc. 1981 Jan;73(1):43-5.
Abstract
There has been an increased incidence of pneumococcal infections in patients with sickle cell disease. Two immunological defects, functional asplenia and decreased pneumococcal serum opsonins due to a defect in the alternate pathway, have been shown to have a causal relationship to this increased incidence. The pneumococcal vaccine has been tried in children with sickle cell disease and failures have been reported in the literature. Clinical trials are now underway to determine the best method to prevent pneumococcal infections in children with sickle cell disease, that is by use of a vaccine, penicillin, or both.
摘要
镰状细胞病患者中肺炎球菌感染的发病率有所上升。已证实两种免疫缺陷，即功能性无脾和由于替代途径缺陷导致的肺炎球菌血清调理素减少，与这种发病率上升存在因果关系。肺炎球菌疫苗已在镰状细胞病患儿中试用，文献中报道了失败案例。目前正在进行临床试验，以确定预防镰状细胞病患儿肺炎球菌感染的最佳方法，即使用疫苗、青霉素或两者并用。
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本文引用的文献
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