Rouzer C A, Cerami A
Mol Biochem Parasitol. 1980 Oct;2(1):31-8. doi: 10.1016/0166-6851(80)90046-8.
Rabbits infected with Trypanosoma brucei brucei develop a hypertriglyceridemia characterized by an increase in very low density lipoprotein and, to a lesser extent, low density lipoprotein, with a decrease in high density lipoprotein. Triglyceride production studies showed that the triglyceride production rate was not significantly different in trypanosome-infected rabbits from controls. Studies of triglyceride degradation using very low density lipoprotein triglyceride endogenously labelled with [3H]palmitate demonstrated a marked slowing of triglyceride removal in the infected rabbits when compared to controls. Lipase activity in post-heparin plasma was found to be deficient in trypanosome-infected animals. Furthermore, the greater the decrease in lipolytic activity, the greater the increase in serum triglyceride level. We conclude that the hypertriglyceridemia associated with T. b. brucei infection in rabbits results predominantly from a defect in triglyceride degradation.
感染布氏布氏锥虫的兔子会出现高甘油三酯血症，其特征是极低密度脂蛋白增加，低密度脂蛋白也有一定程度增加，而高密度脂蛋白减少。甘油三酯生成研究表明，锥虫感染的兔子与对照组相比，甘油三酯生成率没有显著差异。使用内源性标记有[3H]棕榈酸的极低密度脂蛋白甘油三酯进行甘油三酯降解研究表明，与对照组相比，感染兔子的甘油三酯清除明显减慢。发现锥虫感染动物的肝素后血浆中的脂肪酶活性不足。此外，脂解活性降低越大，血清甘油三酯水平升高就越大。我们得出结论，兔子感染布氏布氏锥虫相关的高甘油三酯血症主要是由甘油三酯降解缺陷引起的。
