四氯化碳诱导的脂质过氧化在体内外的氧依赖性
Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo.
作者信息
Kieczka H, Kappus H
出版信息
Toxicol Lett. 1980 Mar;5(3-4):191-6. doi: 10.1016/0378-4274(80)90058-2.
PMID:7466845
Abstract
Rat liver microsomes showed an atypical oxygen dependence of carbon tetrachloride (CCL4)-induced malondialdehyde formation with a maximum at ca. 7% O2 and a minimum at ca. 15% O2. Rats treated with CCl4 expired less ethane under high oxygen concentrations and more ethane under low oxygen concentrations. The initiation of CCl4-induced lipid peroxidation in the liver would appear to be influenced by the oxygen concentrations present in the hepatocytes.
摘要
大鼠肝微粒体显示出四氯化碳（CCl4）诱导的丙二醛形成对氧的非典型依赖性，在约7%氧气浓度时达到最大值，在约15%氧气浓度时达到最小值。用CCl4处理的大鼠在高氧浓度下呼出的乙烷较少，而在低氧浓度下呼出的乙烷较多。肝中CCl4诱导的脂质过氧化的起始似乎受肝细胞中存在的氧浓度影响。
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