Hasselgren P O, Almersjö O, Gustavsson B, Rosengren K
Acta Chir Scand. 1980;146(4):271-5.
The effects of liver dearterialization on the rate of amino acid incorporation into liver and tumor proteins were studied with an in vitro method in seven patients with liver metastases. Before liver dearterialization the incorporation rate was 0.074 +/- 0.020 nmol leucine x mg prot-1 x h-1 in liver tissue and 0.234 +/- 0.049 nmol leucine x mg prot-1 x h-1 in tumor tissue. After dearterialization for 1 h the incorporation rate was reduced to about half of the initial values in both liver and tumor tissue. The vascularity of the tumors was evaluated from preoperative hepatic angiograms. The reduction of the incorporation rate was more pronounced in highly vascularized tumors than in poorly vascularized tumors and liver tissue. The clinical implications of a more pronounced metabolic effect of the dearterialization in high vascularized tumors are discussed.
采用体外方法对7例肝转移患者研究了肝去动脉化对氨基酸掺入肝和肿瘤蛋白速率的影响。肝去动脉化前，肝组织中掺入速率为0.074±0.020 nmol亮氨酸×mg蛋白⁻¹×h⁻¹，肿瘤组织中为0.234±0.049 nmol亮氨酸×mg蛋白⁻¹×h⁻¹。去动脉化1小时后，肝和肿瘤组织中的掺入速率均降至初始值的约一半。根据术前肝血管造影评估肿瘤的血管分布。高血管化肿瘤中掺入速率的降低比低血管化肿瘤和肝组织中更明显。讨论了高血管化肿瘤中去动脉化更显著的代谢效应的临床意义。
