Depaulo J R, Correa E I, Sapir D G
Am J Psychiatry. 1981 Mar;138(3):324-7. doi: 10.1176/ajp.138.3.324.
Recently published studies vary widely in the quantitative assessment of glomerular filtration rate (GFR) in lithium-treated patients. Therefore, the authors tested 99 lithium-treated manic-depressive patients using several techniques to measure GFR. Ten of 86 patients who had no history of renal disease had mildly low creatinine clearance values. Significant correlations, which were not age-related, between the serum creatinine, Cockroft creatinine clearance, and duration of lithium therapy suggest a relationship between chronic lithium therapy and declining GFR. Since serum creatinine alone was insensitive, the authors recommend the use of duplicate classical creatinine clearances confirmed by Cockroft values to monitor GFR during lithium treatment.
最近发表的研究在锂治疗患者的肾小球滤过率（GFR）定量评估方面差异很大。因此，作者使用几种技术对99名接受锂治疗的躁郁症患者进行了GFR测量测试。86名无肾脏疾病史的患者中有10名肌酐清除率值轻度偏低。血清肌酐、Cockcroft肌酐清除率与锂治疗持续时间之间存在非年龄相关的显著相关性，这表明慢性锂治疗与GFR下降之间存在关联。由于仅血清肌酐不敏感，作者建议在锂治疗期间使用经Cockcroft值确认的重复经典肌酐清除率来监测GFR。
