胎盘抗体转移：母体感染艾滋病毒和胎盘疟疾的影响
Placental antibody transfer: influence of maternal HIV infection and placental malaria.
作者信息
de Moraes-Pinto M I, Verhoeff F, Chimsuku L, Milligan P J, Wesumperuma L, Broadhead R L, Brabin B J, Johnson P M, Hart C A
机构信息
Department of Medical Microbiology, University of Liverpool.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1998 Nov;79(3):F202-5. doi: 10.1136/fn.79.3.f202.
AIM
To determine the influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia on transplacental IgG antibody transfer.
METHODS
One hundred and eighty materno-neonatal pairs from a Malawian population were assessed. Cord and maternal serum samples were tested for total serum IgG antibody titres using nephelometry, and for specific IgG antibody titres to Streptococcus pneumoniae, measles, and tetanus toxoid antibodies using an enzyme linked immunosorbent assay (ELISA).
RESULTS
Multiple regression analyses showed that placental malaria was associated with a decrease in placental IgG antibody transfer to S pneumoniae and measles to 82% and 81%, respectively. Maternal HIV infection was associated with a reduction in IgG antibody transfer to S pneumoniae to 79%; raised maternal total serum IgG titres were correlated with S pneumoniae and measles IgG antibody transfer reduction to 86% and 87%, respectively. No effect was seen with tetanus toxoid antibody transfer.
CONCLUSION
The combined influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia seems to be linked to the low transplacental antibody transfer observed in the Malawian population.
目的
确定胎盘疟疾、孕产妇HIV感染和孕产妇高丙种球蛋白血症对经胎盘IgG抗体转移的影响。
方法
对来自马拉维人群的180对母婴进行评估。使用散射比浊法检测脐带血和母体血清样本中的总血清IgG抗体滴度，并使用酶联免疫吸附测定（ELISA）检测针对肺炎链球菌、麻疹和破伤风类毒素抗体的特异性IgG抗体滴度。
结果
多元回归分析表明，胎盘疟疾与经胎盘向肺炎链球菌和麻疹的IgG抗体转移分别减少至82%和81%有关。孕产妇HIV感染与向肺炎链球菌的IgG抗体转移减少至79%有关；孕产妇总血清IgG滴度升高与向肺炎链球菌和麻疹的IgG抗体转移分别减少至86%和87%相关。破伤风类毒素抗体转移未见影响。
结论
胎盘疟疾、孕产妇HIV感染和孕产妇高丙种球蛋白血症的综合影响似乎与马拉维人群中观察到的经胎盘抗体转移率低有关。
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