Slager U T, Anderson V M, Handmaker S D
Arch Neurol. 1981 Feb;38(2):103-8. doi: 10.1001/archneur.1981.00510020061009.
We report the first histologic findings of the CNS in cephalothoracopagus janiceps monosymmetros. The findings are compared with the other ten reported cases of this type of conjoined twin. The faces and CNSs showed asymmetry of development manifested chiefly in the prosencephalon, specifically the cortical gyri, corpus callosum, and subependymal mantle layer. It is difficult to explain discordance for congenital malformations in monovular or conjoined twins by either genetic or environmental mechanisms. It appears related to the vascular supply of the brain and a state of chronic ischemia rather than to a discrete insult and developmental arrest at a specific time during embryogenesis.
我们报告了单对称头胸联体儿中中枢神经系统（CNS）的首例组织学发现。将这些发现与其他十例该类型联体双胎的报告病例进行了比较。面部和中枢神经系统显示出发育不对称，主要表现在前脑，特别是皮质脑回、胼胝体和室管膜下套层。单卵双胎或联体双胎中先天性畸形的不一致，很难通过遗传或环境机制来解释。这似乎与大脑的血管供应和慢性缺血状态有关，而不是与胚胎发育过程中特定时间的离散损伤和发育停滞有关。
