Leon H A, Serova L V, Landaw S A
Aviat Space Environ Med. 1980 Oct;51(10):1091-4.
Rats were flown aboard the Soviet biosatellite Cosmos 936 for 18.5 d during August, 1977. Five rats were subjected to near-weightless space flight, as with Cosmos 782, and five rats were subjected to a 1-G force via an on-board centrifuge. These rats and three control groups were injected with 2-14C glycine 19 d preflight. The flight rats were recovered from orbit after 18.5 d of space flight. Erythrocyte hemolysis and lifespan were evaluated in the five groups of rats by quantitation of radioactive carbon monoxide exhaled in the breath which arises from the breakdown of the previously labeled hemoglobin. The results support our previous findings wherein hemolysis was found to increase as a result of weightless space flight. A comparison to the centrifuged animals indicates that artificial gravity attenuates the effect of weightlessness on hemolysis and appears to normalize the hemolytic rate in the early postflight period.
1977年8月，大鼠被送上苏联生物卫星宇宙936号，飞行18.5天。与宇宙782号飞行任务一样，五只大鼠经历了近失重太空飞行，另外五只大鼠通过卫星上的离心机受到1个重力加速度的作用。这些大鼠以及三个对照组在飞行前19天被注射了2-¹⁴C甘氨酸。飞行大鼠在太空飞行18.5天后从轨道上回收。通过对呼出的放射性一氧化碳进行定量分析来评估五组大鼠的红细胞溶血和寿命，呼出的放射性一氧化碳来自之前标记的血红蛋白的分解。结果支持了我们之前的发现，即失重太空飞行会导致溶血增加。与经离心处理的动物相比，这表明人工重力减弱了失重对溶血的影响，并且似乎使飞行后早期的溶血速率恢复正常。
