Leon H A, Serova L V, Cummins J, Landaw S A
Aviat Space Environ Med. 1978 Jan;49(1 Pt 1):66-9.
Rats were subjected to 19.5 d of weightless space flight aboard the Soviet biosatellite, Cosmos 782. Based on the output of 14CO, survival parameters of a cohort of erythrocytes labeled 15.5 d preflight were evaluated upon return from orbit. These were compared to vivarium control rats injected at the same time. Statistical evaluation indicates that all survival factors were altered by the space flight. The mean potential lifespan, which was 63.0 d in the control rats, was decreased to 59.0 d in the flight rats, and random hemolysis was increased three-fold in the flight rats. The measured size of the cohort was decreased, lending further support to the idea that hemolysis was accelerated during some portion of the flight. A number of factors that might be contributory to these changes are discussed, including forces associated with launch and reentry, atmospheric and environmental parameters, dietary factors, radiation, and weightlessness.
大鼠搭乘苏联生物卫星“宇宙782号”进行了19.5天的失重太空飞行。根据14CO的输出，对在飞行前15.5天标记的一群红细胞的存活参数在从轨道返回后进行了评估。将这些参数与同时注射的饲养室对照大鼠的参数进行了比较。统计评估表明，太空飞行改变了所有存活因素。对照大鼠的平均潜在寿命为63.0天，飞行大鼠的平均潜在寿命降至59.0天，飞行大鼠的随机溶血增加了两倍。所测量的红细胞群大小减小，进一步支持了在飞行的某些阶段溶血加速的观点。讨论了可能导致这些变化的一些因素，包括与发射和再入相关的力、大气和环境参数、饮食因素、辐射和失重。
