Greco A M, Di Filippo O, Boschi G, de Franciscis A
Boll Soc Ital Biol Sper. 1980 Dec 30;56(24):2598-604.
The Authors studied the effects of proteinic malnutrition when it occurred at various periods in the life of rats: the last 10 days of fetal life; nursing (the first 3 weeks of life); after weaning (up to 42 day). The results show that:--the growth in weight of the animals was severely restrained when protein deficiency occurred in post-natal life;--in any case, the blood levels of hematocrit, hemoglobin and proteins were significantly lowered;--organ functions and development were greatly compromised if malnutrition occurred during the period of their cell division. In fact, a brain damage, estimated by protein and DNA modifications, is the result of protein deficiency in pre-natal and, particularly, in nursing period. The hepatic damage, instead, becomes more evident in post-natal life and specially after weaning since the cell division in the liver continues for a much longer period of time.
胎儿期的最后10天；哺乳期（生命的前3周）；断奶后（直至42日龄）。结果显示：——当出生后发生蛋白质缺乏时，动物的体重增长受到严重抑制；——在任何情况下，血细胞比容、血红蛋白和蛋白质的血液水平均显著降低；——如果在细胞分裂期发生营养不良，器官功能和发育会受到极大损害。事实上，通过蛋白质和DNA改变评估的脑损伤是产前尤其是哺乳期蛋白质缺乏的结果。相反，肝损伤在出生后尤其是断奶后变得更加明显，因为肝脏中的细胞分裂会持续更长时间。
