Loo H, Benyacoub A K, Rovei V, Altamura C A, Vadrot M, Morselli P L
Br J Psychiatry. 1980 Nov;137:444-51. doi: 10.1192/bjp.137.5.444.
Plasma levels of antidepressant drugs were measured in 17 depressed patients at roughly monthly intervals over follow-up periods of three to 26 months. Good results in seven were associated with small fluctuations in level from visit to visit, while big fluctuations were associated with poor outcome. Such fluctuations were probably from poor compliance or drug interaction from self-medication. Severe side effects and cardiotoxicity were associated with high levels.
在17名抑郁症患者中，在三至26个月的随访期内，大致每月测量一次抗抑郁药物的血浆水平。7名患者疗效良好与每次就诊时水平波动较小有关，而波动较大则与疗效不佳有关。这种波动可能是由于依从性差或自行用药导致的药物相互作用。严重副作用和心脏毒性与高血浆水平有关。
