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抗抑郁药长期治疗期间的血浆浓度、信息及治疗依从性。

Plasma concentrations, information and therapy adherence during long-term treatment with antidepressants.

作者信息

Altamura A C, Mauri M

出版信息

Br J Clin Pharmacol. 1985 Dec;20(6):714-6. doi: 10.1111/j.1365-2125.1985.tb05137.x.

DOI:10.1111/j.1365-2125.1985.tb05137.x
PMID:4092003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1400844/
Abstract

The influence of information on drug plasma monitoring during long-term antidepressant therapy in fourteen ambulant, depressed patients was evaluated as variation in the L/D ratio time course. A larger variability in L/D ratio, with higher coefficient of variation and a poorer clinical outcome, was found in non-informed patients. The data support the hypothesis that verbal information on long-term drug monitoring of antidepressants could improve patients' adherence to therapy.

摘要

在14名门诊抑郁症患者的长期抗抑郁治疗期间，通过L/D比随时间变化的情况评估了信息对药物血浆监测的影响。未被告知的患者中发现L/D比的变异性更大，变异系数更高，临床结果更差。这些数据支持这样的假设，即关于抗抑郁药长期药物监测的口头信息可以提高患者对治疗的依从性。

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本文引用的文献

1
Long-term monitoring of tricyclic antidepressant plasma concentrations.三环类抗抑郁药血浆浓度的长期监测。
Br J Psychiatry. 1980 Nov;137:444-51. doi: 10.1192/bjp.137.5.444.
2
Analysis of tricyclic antidepressant drugs by gas chromatography using nitrogen-selective detection with packed and capillary columns.使用填充柱和毛细管柱的氮选择性检测气相色谱法分析三环类抗抑郁药。
J Chromatogr. 1980 Jun 13;182(3-4):349-57. doi: 10.1016/s0378-4347(00)81484-x.
3
Satisfaction, compliance and communication.满意度、依从性与沟通。
Br J Clin Psychol. 1982 Nov;21 (Pt 4):241-54. doi: 10.1111/j.2044-8260.1982.tb00562.x.
4
Influence of age on mianserin pharmacokinetics.年龄对米安色林药代动力学的影响。
Psychopharmacology (Berl). 1982;78(4):380-2. doi: 10.1007/BF00433747.
5
Information, compliance and side-effects: a study of patients on antidepressant medication.信息、依从性与副作用：一项关于服用抗抑郁药物患者的研究。
Br J Clin Pharmacol. 1984 Jan;17(1):21-5. doi: 10.1111/j.1365-2125.1984.tb04993.x.
6
Minimization: a new method of assigning patients to treatment and control groups.最小化法：一种将患者分配到治疗组和对照组的新方法。
Clin Pharmacol Ther. 1974 May;15(5):443-53. doi: 10.1002/cpt1974155443.
7
Effects of written drug information on patient knowledge and compliance: a literature review.书面药物信息对患者知识及依从性的影响：一项文献综述
Am J Public Health. 1979 Jan;69(1):47-52. doi: 10.2105/ajph.69.1.47.