抗抑郁药长期治疗期间的血浆浓度、信息及治疗依从性。
Plasma concentrations, information and therapy adherence during long-term treatment with antidepressants.
作者信息
Altamura A C, Mauri M
出版信息
Br J Clin Pharmacol. 1985 Dec;20(6):714-6. doi: 10.1111/j.1365-2125.1985.tb05137.x.
Abstract
The influence of information on drug plasma monitoring during long-term antidepressant therapy in fourteen ambulant, depressed patients was evaluated as variation in the L/D ratio time course. A larger variability in L/D ratio, with higher coefficient of variation and a poorer clinical outcome, was found in non-informed patients. The data support the hypothesis that verbal information on long-term drug monitoring of antidepressants could improve patients' adherence to therapy.
摘要
在14名门诊抑郁症患者的长期抗抑郁治疗期间，通过L/D比随时间变化的情况评估了信息对药物血浆监测的影响。未被告知的患者中发现L/D比的变异性更大，变异系数更高，临床结果更差。这些数据支持这样的假设，即关于抗抑郁药长期药物监测的口头信息可以提高患者对治疗的依从性。
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